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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Embelin, Venetoclax
Phytochemical Name Embelin (PubChem CID: 3218 )
Anticancer drug Name Venetoclax (PubChem CID: 49846579 )
Structure of
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2D MOL 3D MOL
Structure of
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Combination Pair ID: 302
Ref_1
Pair Name Embelin, Venetoclax
Disease Info [ICD-11: 2A60.Z] Acute myeloid leukemia Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression XIAP hsa331
In Vitro Model MOLM-13 Adult acute myeloid leukemia Homo sapiens (Human) CVCL_2119
MV4-11 Childhood acute monocytic leukemia Homo sapiens (Human) CVCL_0064
OCI-AML-3 Adult acute myeloid leukemia Homo sapiens (Human) CVCL_1844
Kasumi-1 Childhood acute myeloid leukemia with maturation Homo sapiens (Human) CVCL_0589
Result The inhibition of both apoptosis inhibitory players, BCL2 and XIAP, by venetoclax and embelin, respectively, potentiated their cytotoxic effects in AML cell lines.
03. Reference
No. Title Href
1 Embelin potentiates venetoclax-induced apoptosis in acute myeloid leukemia cells. Toxicol In Vitro. 2021 Oct;76:105207. doi: 10.1016/j.tiv.2021.105207. Click
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